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. Author manuscript; available in PMC: 2017 Oct 1.
Published in final edited form as: Adv Healthc Mater. 2016 Sep 1;5(20):2628–2635. doi: 10.1002/adhm.201600415

Figure 4.

Figure 4

A local delivery of paclitaxel is needed to promote significant DRG neurite extension. Paclitaxel-loaded PLA microfibers were placed in CellCrown™ inserts (A) and suspended above cells cultured on either TCPS (B) or aligned PLA microfibers (C). A modest increase in neurite extension is observed when paclitaxel is released from paclitaxel-loaded microfibers suspended in CellCrowns™ above DRG neurons cultured on TCPS and PLA microfibers alone, but the maximum neurite extension only occurred when the cells were directly in contact with the paclitaxel-loaded microfibers (D). Scale bar: B–C, 40 µm. (p < 0.001, n = 7 – 10).