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. Author manuscript; available in PMC: 2017 Oct 1.
Published in final edited form as: Adv Healthc Mater. 2016 Sep 1;5(20):2628–2635. doi: 10.1002/adhm.201600415

Figure 5.

Figure 5

The mechanism and surface topography of the local delivery of paclitaxel determines DRG neurite extension. DRG neurons were cultured for five days on PLA films (A) and randomly oriented fibers (C) that were loaded with and without paclitaxel. Although a slight increase in neurite extension was observed among these groups (B, D, E), significant neurite extension only occurred when the microfibers were aligned and coupled with the local release of paclitaxel (E). Scale bars: A, C, 20 µm; B, D, 100 µm. (p < 0.001, n = 9 – 10).