Figure 8.
A local release of paclitaxel from aligned PLA microfibers significantly promotes neurite extension under inhibitory conditions similar to those seen after a spinal cord injury. Isolated DRG neurons were cultured on an uncoated surface, laminin only, or laminin/aggrecan-coated tissue culture polystyrene, aligned PLA microfibers only, or aligned paclitaxel-loaded PLA microfibers. Paclitaxel-loaded microfibers significantly promoted neurite extension than PLA microfibers under both a growth-conducive environment and inhibitory environment (*p < 0.001, **p < 0.005, n = 5 – 10).
