Table III.
Proton Pump Inhibitor Users with and without sterile pyuria and risk of AKI
Odds Ratio (95% confidence interval), p value | ||||
---|---|---|---|---|
No acid suppressive medications | Proton Pump Inhibitor Use and sterile pyuria | Proton Pump Inhibitor Use without sterile pyuria | Histamine Receptor Antagonist | |
Pyuria defined by leukocyte esterase positivity | ||||
Unadjusted | Ref | 1.80 0.90–3.311 p=0.09 |
1.52 1.17–1.97 p<0.001 |
1.47 0.92–2.27 p=0.10 |
Adjusted1 | Ref. | 1.16 0.54–2.27 p=0.69 |
1.10 0.82–1.47 p=0.51 |
1.21 0.73–1.92 p=0.44 |
Pyuria defined by > 5 WBC’s/hpf | ||||
Unadjusted | Ref. | 2.66 1.20–5.47 p=0.02 |
1.52 1.06–2.16 p=0.02 |
1.72 1.20–5.47 p=0.06 |
Adjusted2 | Ref. | 1.64 0.70–3.62 p=0.24 |
1.05 0.69–1.57 p=0.80 |
1.58 0.85–2.83 p=0.14 |
Both analyses adjusted per model 5.
N=2,360 in adjusted analysis
N=1,173 in adjusted analysis