Table III.

Proton Pump Inhibitor Users with and without sterile pyuria and risk of AKI

	Odds Ratio (95% confidence interval), p value
	No acid suppressive medications	Proton Pump Inhibitor Use and sterile pyuria	Proton Pump Inhibitor Use without sterile pyuria	Histamine Receptor Antagonist
Pyuria defined by leukocyte esterase positivity
Unadjusted	Ref	1.80 0.90–3.311 p=0.09	1.52 1.17–1.97 p<0.001	1.47 0.92–2.27 p=0.10
Adjusted1	Ref.	1.16 0.54–2.27 p=0.69	1.10 0.82–1.47 p=0.51	1.21 0.73–1.92 p=0.44
Pyuria defined by > 5 WBC’s/hpf
Unadjusted	Ref.	2.66 1.20–5.47 p=0.02	1.52 1.06–2.16 p=0.02	1.72 1.20–5.47 p=0.06
Adjusted2	Ref.	1.64 0.70–3.62 p=0.24	1.05 0.69–1.57 p=0.80	1.58 0.85–2.83 p=0.14

Both analyses adjusted per model 5.

¹N=2,360 in adjusted analysis

²N=1,173 in adjusted analysis