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. Author manuscript; available in PMC: 2017 Dec 1.
Published in final edited form as: J Clin Pharmacol. 2016 Sep 12;56(12):1500–1506. doi: 10.1002/jcph.805

Table III.

Proton Pump Inhibitor Users with and without sterile pyuria and risk of AKI

Odds Ratio (95% confidence interval), p value
No acid suppressive medications Proton Pump Inhibitor Use and sterile pyuria Proton Pump Inhibitor Use without sterile pyuria Histamine Receptor Antagonist
Pyuria defined by leukocyte esterase positivity
Unadjusted Ref 1.80
0.90–3.311
p=0.09
1.52
1.17–1.97
p<0.001
1.47
0.92–2.27
p=0.10
Adjusted1 Ref. 1.16
0.54–2.27
p=0.69
1.10
0.82–1.47
p=0.51
1.21
0.73–1.92
p=0.44
Pyuria defined by > 5 WBC’s/hpf
Unadjusted Ref. 2.66
1.20–5.47
p=0.02
1.52
1.06–2.16
p=0.02
1.72
1.20–5.47
p=0.06
Adjusted2 Ref. 1.64
0.70–3.62
p=0.24
1.05
0.69–1.57
p=0.80
1.58
0.85–2.83
p=0.14

Both analyses adjusted per model 5.

1

N=2,360 in adjusted analysis

2

N=1,173 in adjusted analysis

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