Table 1.

Parameters of the fast sodium current

Source	Seutin and Engel (2010) (data)	Ding et al. (2011) (data)	Yu and Canavier (2015) (model)	Qian et al. (2014) (model)	Oster (2015) (model)
mHALF, mV	−9.6*	−26.7	−30	−30	−7
mSLOPE, mV	12	7.3	13	9.7	9.2†
hHALF, mV	−48.9*	−61.3	−54	−54	−38
hSLOPE, mV	−10.5	−10.1	−12.8	−10.7	−4†
hsHALF, mV			−54.8	−54.8
hsSLOPE, mV			−1.57	−1.57

The fit in Seutin and Engel (2010) did not consider simultaneous fitting of the parameters of activation and activation to the voltage clamp data, but they fit them separately assuming no inactivation occurred before the peak.

^*Goldman-Hodkin-Katz formalism was used in the fit rather than an ohmic dependence on membrane potential. The sodium current description in Qian et al. (2014) was taken from the fit given in Tucker et al. (2012) to the data from Seutin and Engel (2010), considering simultaneous activation and inactivation and ohmic dependence of driving force on membrane potential as in the original Hodgkin and Huxley (1952) formalism. †Approximate value because a Boltzman function description was not used.