Table 1.
MICs and Fks mutation for isolates of Candida species studied.
| Isolate | Species | Day of isolation | Site of isolation |
MICa(mg/L) |
Fksmutation | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Fluco | Vori | Posa | Caspo | Mica | Anidula | 5FC | AmphoB | |||||
| CNRMA13.446 | C. glabrata | day 0 | blood | 8 | 0,5 | 1 | 0,06 | 0,03 | 0,06 | 0,124 | 0,125 | ND |
| CNRMA13.526 | C. tropicalis | day 32 | blood | 1 | 8 | 0,125 | 0,03 | 0,03 | 0,03 | 0,124 | 0,125 | WT |
| CNRMA13.694 | C. tropicalis | day 93 | blood | 0,5 | 0,06 | 0,06 | 4 | 0,5 | 0,5 | 0,124 | 0,06 | S645P (HS1) |
| CNRMA13.778 | C. tropicalis | day 139 | heart valve | 0,5 | 0,06 | 0,03 | 4 | 0,5 | 0,5 | 0,124 | 0,06 | S645P (HS1) |
| CNRMA13.695 | C. albicans | day 94 | blood | 0,124 | 0,014 | 0,014 | 4 | 2 | 0,25 | 0,124 | 0,06 | S645P (HS1) |
| CNRMA13.779 | C. albicans | day 139 | heart valve | 0,124 | 0,014 | 0,014 | 4 | 1 | 0,25 | 0,124 | 0,03 | S645P (HS1) |
ND: not done, WT: wild-type protein sequence in comparison with type strain ATCC750, susceptible to echinocandins.
a
MIC: Minimum Inhibitory Concentration, Fluco: fluconazole, Vori: voriconazole, Posa: posaconazole, Caspo: caspofungin, Mica: micafungin, Anidula: anidulafungin, 5FC: flucytosin, AmphoB: amphotericin B.