Table 1.
CD predisposing HLA-DQ frequencies in CD patients and controls and general genetic risk.
| Genotypes | DQB1∗02 status | CD% (n = 237) | Control (n = 237) | pCD/control | General risk |
|---|---|---|---|---|---|
| 1 : 100 | |||||
| DQ2.5/DQ2.5 | (β2/β2) | 6.33% (15) | 0.42% (1) | 0.0004 | 1 : 7 |
| DQ2.5/DQ2.2 | (β2/β2) | 25.31% (60) | 2.53% (6) | <0.0001 | 1 : 10 |
| DQ2.5/DQ8 | (β2/x) | 8.86% (21) | 1.68% (4) | 0.0007 | 1 : 19 |
| DQ2.5 | (β2/x) trans | 10.54% (25) | 2.11% (5) | 0.0002 | 1 : 20 |
| (β2/x) cis | 32.91% (78) | 11% (26) | <0.0001 | 1 : 30 | |
| DQ2.2/DQ8 | (β2/x) | 6.33% (15) | 2.53% (6) | 0.0718 | 1 : 40 |
| DQ2.2/DQ2.2 | (β2/β2) | 0.84% (2) | 2.11% (5) | 0.4496 | 1 : 251 |
| DQ8 | — | 3.8% (9) | 10.97% (26) | 0.0043 | 1 : 289 |
| DQ2.2 | (β2/x) | 2.53% (6) | 13.92% (33) | 0.0001 | 1 : 550 |
| DQ8/α5 | — | 0.42% (1) | 4.22% (10) | 0.0108 | 1 : 1005 |
| α5 | — | 1.3% (3) | 20.25% (48) | <0.0001 | 1 : 1594 |
| Absent | — | 0.84% (2) | 25.31% (60) | <0.0001 | 1 : 3014 |
| α8 | — | 0.0% (0) | 2.95% (7) | 0.0149 | ND |
ND: risk not determined; CD: celiac disease; β2 refers to DQB1∗02; α5 refers to DQA1∗05; α8 refers to DQA1∗03:01; x denotes not determined allele; β2/β2 refers to DQB1∗02 homozygosis; β2/x refers to DQB1∗02 heterozygosis; p value.