Table 5.

COX activity in fetuses (U/mg of protein).

Groups	Total COX		COX-1		COX-2
Vehicle-treated control (V-TC) (n = 69)	91.21 ± 5.93		12.24 ± 2.20		78.96 ± 6.52
LA-treated control (LA-TC) (n = 61)	94.30 ± 4.22		14.33 ± 2.45		79.97 ± 7.89
	Nonmalformed	Malformed∗	Nonmalformed	Malformed	Nonmalformed	Malformed∗
Vehicle-treated diabetic (V-TD) (n = 48)	88.74 ± 4.16	52.80 ± 2.11	11.31 ± 1.24	10.28 ± 1.43	77.43 ± 5.28	42.52 ± 2.54
LA-treated diabetic (LA-TD) (n = 59)	86.89 ± 6.46	60.54 ± 4.02	12.47 ± 6.20	8.58 ± 1.34	74.43 ± 5.83	47.96 ± 3.04

^∗Significantly lower (p < 0.05) compared with fetuses from V-TC, LA-TC, and nonmalformed groups of both groups of diabetic rats.