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IL-17-stimulated MMP-9 expression is inhibited by Doxycycline. (a) IL-17 induced MMP-9 activation in the presence or absence of 5 or 10 μg/mL of Doxy determined by zymography. (b) Promoter transactivation induced by IL-17 in the presence or absence of Doxy. (c) IL-17-induced MMP-9 mRNA expression determined by RT-PCR. GAPDH is used as gel loading control.
