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Summary of gene expression in OA articular cartilage explants.
| Gene expression response in patients treated with DFO | ||||
|---|---|---|---|---|
| Downregulation | Upregulation | No change | No expression | |
| MMP-1 | 7 | 0 | 0 | 0 |
| MMP-13 | 6 | 0 | 0 | 1 |
| Cathepsin K | 3 | 0 | 3 | 1 |
| COL10A1 | 7 | 0 | 0 | 0 |
| IL-1β | 7 | 0 | 0 | 0 |
| TNFα | 7 | 0 | 0 | 0 |
| Glut 1 | 1 | 3 | 3 | 0 |
| PGK1 | 3 | 4 | 0 | 0 |
| PKM2 | 2 | 3 | 2 | 0 |
| IDH3G | 1 | 5 | 0 | 1 |
| SDH | 0 | 7 | 0 | 0 |
| OGDH | 0 | 6 | 1 | 0 |
| MDH2 | 0 | 7 | 0 | 0 |
| AMPK | 0 | 6 | 1 | 0 |
| HIF1α | 1 | 6 | 0 | 0 |
| COL2A1 | 1 | 5 | 1 | 0 |
