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. 2016 Dec 14;6:38882. doi: 10.1038/srep38882

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Copyright © 2016, The Author(s)

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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The 53 proteins of the pellicle (blue) interact with 405 salivary proteins (orange) and 28 ligands (green).The interactome is highly dominated by 5 proteins (highlighted by protein name), which show >50 interactions each. Interactions extracted from external sources are dark grey, predicted protein-ligand interactions are shown by red lines. Each protein is specified by its gene ID. Ligand IDs are based on Protein Data Bank ligand abbreviations (www.rcsb.org). A high resolution version of this figure is available in the online supplement. ALBU = Serum albumin, ANXA1 = Annexin A1, ENOA = Alpha-enolase, G3P = Glyceraldehyde-3-phosphate dehydrogenase, 1433Z = 14-3-3 protein zeta/delta.