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. 2016 Dec 14;6:38892. doi: 10.1038/srep38892

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Copyright © 2016, The Author(s)

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Homologous stem-loop structures in the cleavage site regions of H3 (a), H5 (b) and H6 (c) HA RNAs. The GGN codon coding for the first Gly residue of the HA2 chain downstream of the cleavage site is shown by an asterisk. Nucleotide covariations are shown in red. Folding free energies ΔG°₃₇ (kcal/mol) are given for both positive sense RNA structures and corresponding negative-sense vRNA conformations. The covariation 1036–1057 in H5 HA RNA (b) involves two transversions between A.C and C.A mismatches in positive-sense mRNA, and these transversions correspond to the covariation between wobble base pairs G.U and U.G in vRNA. The 1010–1070 covariation in H6 HA RNA (c) also includes two transversions, R = A or G.