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. 2016 Dec 14;6:38892. doi: 10.1038/srep38892

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Copyright © 2016, The Author(s)

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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The gs/GD/96 phylogenetic tree⁴¹ is used in a simplified form to show the typical changes of the folding free energy ΔG°₃₇ (kcal/mol) in the tree branches. Structure-stabilizing changes are shown in red. The clades are designated according to accepted nomenclature⁴¹, and the phylogenetic position of HP HA segments of reassortant H5N2, H5N5, H5N6, H5N8 strains in clade 2.3.4.4 is indicated.