. 2016 Dec 14;6:39048. doi: 10.1038/srep39048

Table 2. Summary of inhibitory activities in [³H]DA uptake assay in WT and mutated hDAT in the presence of DA, cocaine and GBR12909.

IC₅₀ (nM)	WT hDAT	H547A	H547P	H547R	H547D	Y548H	Y551H
DA	1720 ± 206	5356 ± 978^*	300 ± 48^*	2454 ± 366	1168 ± 154	1744 ± 105	663 ± 70^*
Cocaine	294 ± 34	338 ± 26	238 ± 26	470 ± 33	198 ± 32	77 ± 9^*	59 ± 7^*
GBR12909	262 ± 42	270 ± 85	332 ± 13	98 ± 17	344 ± 18	162 ± 44	279 ± 46

Data are presented as mean ± S.E.M. values from five to seven independent experiments performed in duplicates. *p < 0.05 compared with WT hDAT (unpaired Student’s t test).

Table 2. Summary of inhibitory activities in [3H]DA uptake assay in WT and mutated hDAT in the presence of DA, cocaine and GBR12909.

Table 2. Summary of inhibitory activities in [³H]DA uptake assay in WT and mutated hDAT in the presence of DA, cocaine and GBR12909.