Table 4.
Logarithmic gains of the independent variables with respect to metabolites concentration and with respect to fluxes of the model in Fig. 3. The metabolite most influenced by changes in the independent variables is l-Dopamine (l-DOPA)-int. The influence of the fluxes on metabolite concentrations shows that almost all the magnitudes are less than 1
| Metabolite concentration |
Flux of metabolite |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Equation | Variable | Kinetic order | X 1 | X 2 | X 3 | X 4 | V(X1) | V(X2) | V(X3) | V(X4) |
| IPC | PhytoCera | g(1,5) | 0.35 | – | – | – | 0.35 | – | – | – |
| PIb | g(1,6) | 0.79 | – | – | – | 0.79 | – | – | – | |
| Ipc1c | g(1,7) | 3.56 | – | – | – | 3.56 | – | – | – | |
| IPCd | h(1,1) | – | – | – | – | – | – | – | – | |
| DAG | PhytoCer | g(2,5) | – | 0.35 | −0.94 | – | – | 0.35 | – | – |
| PI | g(2,6) | – | 0.79 | −2.14 | – | – | 0.79 | – | – | |
| Ipc1 | g(2,7) | – | 3.56 | −9.58 | – | – | 3.56 | – | – | |
| DAGe | h(2,2) | – | −3.64 | 9.80 | – | – | – | – | – | |
| l-DOPA int | l-DOPA-extf | g(3,9) | – | – | 11.56 | 4.29 | – | – | 4.29 | 4.29 |
| Transport | g(3,10) | – | – | 3.38 | 1.25 | – | – | 1.25 | 1.25 | |
| DAG | h(3,2) | – | – | −9.80 | −3.64 | – | – | – | −3.64 | |
| l-DOPA-intg | h(3,3) | – | – | – | – | – | – | – | – | |
| Pkc1h | h(3,8) | – | – | −10.73 | −3.98 | – | – | – | −3.98 | |
| Laccase | h(3,11) | – | – | −19.71 | −7.31 | – | – | – | −7.31 | |
| Melanin | DAG | g(4,2) | – | – | – | 3.64 | – | – | – | 3.64 |
| l-DOPA-int | g(4,3) | – | – | – | – | – | – | – | – | |
| Pkc1 | g(4,8) | – | – | – | 3.98 | – | – | – | 3.98 | |
| Laccase | g(4,11) | – | – | – | 7.31 | – | – | – | 7.31 | |
| Melanin | h(4,4) | – | – | – | – | – | – | – | – | |
a
Phytoceramide
b
Phosphatidylinositol
c
Inositol phosphoryl ceramide synthase 1
d
Inositol phosphoryl ceramide
e
Diacylglycerol
f
l-Dopamine extracellular
g
l-Dopamine intracellular
h
Protein kinase C 1