Table 5.

Sensitivity of the kinetic orders on the metabolite concentrations and fluxes of the model in Fig. 2. The largest negative influence is on l-Dopamine (l-DOPA) concentration, X₃. This metabolite responds to a change in the kinetic order associate to degradation h_3,11; increase its concentration when this parameter decreases. Additionally, S(X₄, g_4,11) indicates an increase in melanin concentration, X₄ when its own synthesis increases

		Metabolite concentration				Flux of metabolite
Independent variable		X 1	X 2	X 3	X 4	V(X1)	V(X2)	V(X3)	V(X4)
Phytoceramide	X 5	0.26	0.26	−0.71	–	0.26	0.26	–	–
PIa	X 6	0.52	0.52	−1.41	–	0.52	0.52	–	–
Ipc1b	X 7	1.00	1.00	−2.70	–	1.00	1.00	–	–
Pkc1c	X 8	–	–	−2.70	–	–	–	–	–
l-DOPA-extd	X 9	–	–	0.84	0.31	–	–	0.31	0.31
Transport	X 10	–	–	2.70	1.00	–	–	1.00	1.00
Laccase	X 11	–	–	−2.70	–	–	–	–	–

^aPhosphatidylinositol

^bInositol phosphoryl ceramide synthase 1

^cProtein kinase C 1

^dl-Dopamine extracellular