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The miR-146a-5p-mediated EMT process depends on Notch2. (A, B) miR-146a-5p inhibitor caused an increase in ESCC cells' invasive ability, whereas shRNA-Notch2 could abolish this change. (C, D) miR-146a-5p inhibitor led to increase of Snail and Vimentin and decrease of E-cadherin, whereas co-transfection with shRNA-Notch2 partially abolished these changes. *P<0.05; **P<0.01; ***P<0.001.
