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. 2016 Dec 13;6:45. doi: 10.1186/s13395-016-0117-3

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© The Author(s). 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — Average weekly body weights (a), food consumption (b), running distance (c), speed (d), and external work (e) in males and females in both SED and RWE cohorts over 34 weeks. The asterisks indicate significant differences between sedentary and exercised mice (data were pooled for sex; *P < 0.05; **P < 0.01). Diamond indicates a significant effect of age ^♦ P < 0.05. Data for “speed” at week 2 are missing due to technical issues. For each weekly time point, data are mean ± SEM. N = 6–10 mice per group