Table 2.
Risk loci for PD identified through GWA. Loci in grey indicate a second risk allele that confers an effect independent of a primary risk allele at the same locus.
| SNP | Chr | Base Pair | Nominated Gene | OR |
|---|---|---|---|---|
| rs35749011 | 1 | 155,135,036 | GBA/SYT11 | 1.824 |
| rs114138760 | 1 | 154,898,185 | GBA/SYT11 | 1.586 |
| rs823118 | 1 | 205,723,572 | RAB7L1/NUCKS1 | 1.122 |
| rs10797576 | 1 | 232,664,611 | SIPA1L2 | 1.131 |
| rs6430538 | 2 | 135,539,967 | ACMSD/TMEM163 | 0.875 |
| rs1474055 | 2 | 169,110,394 | STK39 | 1.214 |
| rs12637471 | 3 | 182,762,437 | MCCC1 | 0.842 |
| rs34311866 | 4 | 951,947 | TMEM175/GAK/DGKQ | 0.786 |
| rs34884217 | 4 | 944,210 | TMEM175/GAK/DGKQ | 1.105 |
| rs11724635 | 4 | 15,737,101 | BST1 | 1.126 |
| rs6812193 | 4 | 77,198,986 | FAM47E/SCARB2 | 0.907 |
| rs356182 | 4 | 90,626,111 | SNCA | 0.76 |
| rs7681154 | 4 | 90,763,703 | SNCA | 0.934 |
| rs9275326 | 6 | 32,666,660 | HLA-DQB1 | 0.826 |
| rs13201101 | 6 | 32,343,604 | HLA-DQB1 | 1.217 |
| rs199347 | 7 | 23,293,746 | GPNMB | 1.11 |
| rs591323 | 8 | 16,697,091 | FGF20 | 0.916 |
| rs117896735 | 10 | 121,536,327 | INPP5F | 1.624 |
| rs329648 | 11 | 133,765,367 | MIR4697 | 1.105 |
| rs76904798 | 12 | 40,614,434 | LRRK2 | 1.155 |
| rs11060180 | 12 | 123,303,586 | CCDC62 | 1.105 |
| rs11158026 | 14 | 55,348,869 | GCH1 | 0.904 |
| rs2414739 | 15 | 61,994,134 | VPS13C | 1.113 |
| rs14235 | 16 | 31,121,793 | BCKDK/STX1B | 1.103 |
| rs11868035 | 17 | 17,715,101 | SREBF/RAI1 | 0.939 |
| rs17649553 | 17 | 43,994,648 | MAPT | 0.769 |
| rs12456492 | 18 | 40,673,380 | RIT2 | 0.904 |
| rs8118008 | 20 | 3,168,166 | DDRGK1 | 1.111 |