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. Author manuscript; available in PMC: 2017 Sep 1.
Published in final edited form as: J Mol Cell Cardiol. 2016 May 26;98:138–145. doi: 10.1016/j.yjmcc.2016.05.014

Figure 1.

Figure 1

Panel A shows the effects of oxidative stress (H2O2, 200 μM) on hCM. Ca++ transient recordings (left) show an increase in Ca++ ALT and CaD under conditions of oxidative stress (H2O2). Graphs (right) show summary data before and after H2O2 at 200 μM where oxidative stress significantly increased Ca++ ALT (n=13, p< 0.001) and CaD (n=8, p<0.0001). Panel B shows the inhibitory effect of Ryanodine (RyR, 10 μM) and Thapsigargin (THAP, 5 μM) on Ca++ transient amplitude († = p< 0.01, ‡ = p< 0.0001, compared to CNTL, n=7).