. Author manuscript; available in PMC: 2016 Dec 14.

Published in final edited form as: JAMA Neurol. 2016 Oct 1;73(10):1231–1237. doi: 10.1001/jamaneurol.2016.2539

Table 2. Generalized Mixed-Effects Model Using the Vascular Risk Factors and Main Variables With LOAD as the Selected Outcome.

Variables	No. of Participants	OR (95% CI)	P Value^a
Model 1^b
Hypertension	5627	0.63 (0.55-0.72)	<.001
T2D	5621	0.87 (0.80-1.17)	.74
Heart disease	5544	0.87 (0.74-1.02)	.09
Stroke	5641	2.23 (1.75-2.83)	<.001
Model 2^c
Hypertension	5308	0.63 (0.54-0.72)	<.001
T2D	5303	0.98 (0.80-1.20)	.83
Heart disease	5228	0.85 (0.71-1.02)	.08
Stroke	5320	2.29 (1.75-2.99)	<.001
Model 3^d
Hypertension	2442	0.67 (0.55-0.84)	<.001
Stroke	2484	2.23 (1.50-3.32)	<.001

Abbreviations: LOAD, late-onset Alzheimer disease; OR, odds ratio; T2D, type 2 diabetes.

Significance was tested after multiple testing adjustment.

Sex, age at baseline, and educational level were entered as covariates.

Additionally adjusted for the apolipoprotein E ε4 allele.

Additionally adjusted for the genetic risk score.