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. 2015 Jul 10;5:10179. doi: 10.1038/srep10179

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Copyright © 2015, Macmillan Publishers Limited

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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(a) Apparent trabecular bone mineral density, (b) bone volume fraction, (c) trabecular number, (d) trabecular thickness, (e) structure model index, and (f) trabecular separation of vertebra L2 of Sprague Dawley rats after treatment with DOI for 6 weeks. Results are expressed as means ± SEM (n = 6; except Premarin group, where n = 3). *p < 0.05, **p < 0.01 compared with the control group (unpaired t-test). Ctl: control group received daily intraperitoneal injections of PBS; Premarin positive control group received daily Premarin (12.4 mg/kg) by oral administration; DOI group: DOI-treated groups received daily intraperitoneal injections of DOI (2.5, 5, and 10 mg/kg).

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