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. 2016 Sep 30;5(11):1625–1630. doi: 10.1242/bio.019976

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© 2016. Published by The Company of Biologists Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Fig. 4. — Results of the histological analysis. (A) Y79 xenograft tumour from a nude mouse eye 6 weeks after injection (25× magnification), the tumour (black star) grows in the vitreous but does not penetrate the retina (black arrow). (B) Y79 xenograft tumour from a nude mouse eye 6 weeks after injection (25× magnification). Here the tumour, after having grown in the vitreous (smaller black star), penetrated the retina and after strong subretinal growth (bigger black star) pressed the retina (black arrow) in direction of the lens (L). (C) Y79 xenograft tumour from a nude mouse eye 9 weeks after injection (25× magnification), the tumour (black star) has replaced all structures of the inner eye, i.e. the vitreous, the retina and the lens and broke through the cornea (out of sight).