Fig. 5.

Pgrmc2 has a sexual dimorphic role in mice and ALADIN KO in female mice leads to an alteration in PGRMC2. (A) Total RNA was isolated from dissected adrenals and gonads of WT and Aaas KO mice. *P<0.05, **P<0.01, ***P<0.001. Significant differences were measured with unpaired Wilcoxon–Mann–Whitney U-test. Boxplot widths are proportional to the square root of the samples sizes. Whiskers indicate the range outside 1.5 times the inter-quartile range (IQR) above the upper quartile and below the lower quartile. Outliers were plotted as dots. (B) Total protein was isolated from dissected adrenals, brain, ovaries and spleen of female WT and Aaas KO mice followed by western blot with indicated antibodies.