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. 1976 Apr;18(1):356–360. doi: 10.1128/jvi.18.1.356-360.1976

Influenza virus RNA's in the cytoplasm of chicken embryo cells treated with 3'-deoxyadenosine.

C L Pridgen
PMCID: PMC515554  PMID: 943576

Abstract

3'-Deoxyadenosine (75 to 100 mug/ml) permitted analysis of the cytoplasmic influencza virus-specific RNAs synthesized early in the replicative cycle-a phase that has hitherto been obscurred by host cell RNA synthesis. In addition, late in the cycle (6 to 8) complementary virus-specific RNA's were the predominantly labeled species, suggesting that higher concentrations of 3'-deoxyadenosine selectively inhibit influenza viral genome replication.

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Selected References

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  1. Avery R. J., Dimmock N. J. Temporal control of transcription of influenza virus RNA. Virology. 1975 Apr;64(2):409–414. doi: 10.1016/0042-6822(75)90117-8. [DOI] [PubMed] [Google Scholar]
  2. Content J., Duesberg P. H. Base sequence differences among the ribonucleic acids of influenza virus. J Mol Biol. 1971 Dec 14;62(2):273–285. doi: 10.1016/0022-2836(71)90427-x. [DOI] [PubMed] [Google Scholar]
  3. Darlington R. W., Portner A., Kingsbury D. W. Sendai virus replication: an ultrastructural comparison of productive and abortive infections in avian cells. J Gen Virol. 1970 Dec;9(3):169–177. doi: 10.1099/0022-1317-9-3-169. [DOI] [PubMed] [Google Scholar]
  4. Duesberg P. H. The RNA of influenza virus. Proc Natl Acad Sci U S A. 1968 Mar;59(3):930–937. doi: 10.1073/pnas.59.3.930. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Etkind P. R., Krug R. M. Influenza viral messenger RNA. Virology. 1974 Nov;62(1):38–45. doi: 10.1016/0042-6822(74)90301-8. [DOI] [PubMed] [Google Scholar]
  6. Kingsbury D. W., Webster R. G. Some properties of influenza virus nucleocapsids. J Virol. 1969 Sep;4(3):219–225. doi: 10.1128/jvi.4.3.219-225.1969. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Krug R. M. Cytoplasmic and nucleoplasmic viral RNPs in influenza virus-infected MDCK cells. Virology. 1972 Oct;50(1):103–113. doi: 10.1016/0042-6822(72)90350-9. [DOI] [PubMed] [Google Scholar]
  8. Mahy B. W., Cox N. J., Armstrong S. J., Barry R. D. Multiplication of influenza virus in the presence of cordycepin, an inhibitor of cellular RNA synthesis. Nat New Biol. 1973 Jun 6;243(127):172–174. doi: 10.1038/newbio243172a0. [DOI] [PubMed] [Google Scholar]
  9. Milcarek C., Price R., Penman S. The metabolism of a poly(A) minus mRNA fraction in HeLa cells. Cell. 1974 Sep;3(1):1–10. doi: 10.1016/0092-8674(74)90030-0. [DOI] [PubMed] [Google Scholar]
  10. Nayak D. P., Baluda M. A. An intermediate in the replication of influenza virus RNA. Proc Natl Acad Sci U S A. 1968 Jan;59(1):184–191. doi: 10.1073/pnas.59.1.184. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Pons M. W. The inhibition of influenza virus RNA synthesis by actinomycin D and cycloheximide. Virology. 1973 Jan;51(1):120–128. doi: 10.1016/0042-6822(73)90372-3. [DOI] [PubMed] [Google Scholar]
  12. Pridgen C., Kingsbury D. W. Adenylate-rich sequences in Sendai virus transcripts from infected cells. J Virol. 1972 Aug;10(2):314–317. doi: 10.1128/jvi.10.2.314-317.1972. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Repik P., Flamand A., Bishop D. H. Effect of interferon upon the primary and secondary transcription of vesicular stomatitis and influenza viruses. J Virol. 1974 Nov;14(5):1169–1178. doi: 10.1128/jvi.14.5.1169-1178.1974. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Scholtissek C., Rott R. Synthesis in vivo of influenza virus plus and minus strand RNA and its preferential inhibition by antibiotics. Virology. 1970 Apr;40(4):989–996. doi: 10.1016/0042-6822(70)90145-5. [DOI] [PubMed] [Google Scholar]
  15. Webster R. G., Campbell C. H., Granoff A. The "in vivo" production of "new" influenza A viruses. I. Genetic recombination between avian and mammalian influenza viruses. Virology. 1971 May;44(2):317–328. doi: 10.1016/0042-6822(71)90263-7. [DOI] [PubMed] [Google Scholar]

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