Figure 3. Analysis of non-monotonicity in the 6 node network from Fig. 1b.
3 and its pharmacological implications. α = 0.5, n = 2.a) Dose-response curve for X1 as function of S1 for S2 = 200 (black solid), and X2 as function of S1 for S2 = 200 (red solid) and of S1 for S2 = 1 (blue solid), showing the non-monotonic response for X2 as function of S1. b) Contour plot showing the toxicity and effectivity of the state of X2 as function of an agonist for S1 for various concentrations of S2. The two horizontal dashed lines at S2 = 200 and S2 = 1 compare to the curves in a).