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. 2015 Jun 18;5:11376. doi: 10.1038/srep11376

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Copyright © 2015, Macmillan Publishers Limited

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a) V, b) S1, and c) S2 for the incoherent topology in Fig. 1d. Shading indicates the regime for which the response X is ON, assuming α = 0.5. a) The dose-response curve for X1 (black) and X2 (red) as function of V. Further the critical concentrations , , are indicated where the state switches from ON to OFF, or vice versa. The symbols indicate the state of the input signals, ■ = (S₁ = OFF, S₂ = OFF), ▲ = (S₁ = OFF, S₂ = ON) ● = (S₁ = ON, S₂ = OFF) ▼ = (S₁ = ON, S₂ = ON) (see Eq. 3). The non-monotonic relation between X2 and V is clearly observed. b) The dose-response curve for for X1 (black) and X2 (red) as function of S₁. Solid lines indicate S₂ = ON, dashed lines S₂ = OFF. The non-monotonic relation between X2 and S1 is clearly observed. c) Similar to b), but with the roles of S₁ and S₂ reversed.

Inline graphic — a) V, b) S1, and c) S2 for the incoherent topology in Fig. 1d. Shading indicates the regime for which the response X is ON, assuming α = 0.5. a) The dose-response curve for X1 (black) and X2 (red) as function of V. Further the critical concentrations , , are indicated where the state switches from ON to OFF, or vice versa. The symbols indicate the state of the input signals, ■ = (S₁ = OFF, S₂ = OFF), ▲ = (S₁ = OFF, S₂ = ON) ● = (S₁ = ON, S₂ = OFF) ▼ = (S₁ = ON, S₂ = ON) (see Eq. 3). The non-monotonic relation between X2 and V is clearly observed. b) The dose-response curve for for X1 (black) and X2 (red) as function of S₁. Solid lines indicate S₂ = ON, dashed lines S₂ = OFF. The non-monotonic relation between X2 and S1 is clearly observed. c) Similar to b), but with the roles of S₁ and S₂ reversed.