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. Author manuscript; available in PMC: 2017 Dec 6.
Published in final edited form as: ChemMedChem. 2016 Nov 10;11(23):2630–2637. doi: 10.1002/cmdc.201600519

Figure 3.

Figure 3

High resolution accurate mass spectra and proposed fragment assignments for 1-M1 (A), 1-M2 (B), 2-M1 (C), 2-M2 (D), 3-M1 (E), 4-M1 (F), and 4-M2 (G). Samples were obtained from incubations with 0.5 mg/mL human liver microsomes and 10 μM of the indicated substrate for 30 minutes at 37 °C in the presence of 100 mM potassium phosphate, pH 7.4, and an NADPH regenerating system. Spectra were collected using a Q-Exactive mass spectrometer. Data are representative results from three independent incubations. Corresponding triple quadrupole MS2 spectra for these metabolites can be found in Figure S1.