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Proposed mechanisms by which 5-methyl tetrahydrofolate (5-MTHF) may increase nitric oxide (NO) synthesis and bioavailability. Abbreviations: 5-MTHF, 5-methyl tetrahydrofolate; BH4, tetrahydrobiopterin; BH2, dihydrobiopterin; NO, nitric oxide; NOS, nitric oxide synthase; O2−, superoxide; ONOO−, peroxynitrite; ROS, reactive oxygen species.
