Figure 4.

Increased cutaneous vasodilation following oral sapropterin or folic acid administration in healthy older adults. Cutaneous vasodilation response to whole-body heat stress (increase in mean body temperature  =  1.0°C) in older adults following placebo and acute sapropterin (10 mg/kg body weight; n  =  9), chronic sapropterin (400 mg twice daily for 4 weeks; n  =  4), or chronic folic acid (5 mg once daily for 6 weeks; n  =  11). Adapted from Stanhewicz et al.⁶⁴ and Stanhewicz et al.¹⁰