Table 2. Results summary for the selected candidate genes.

Gene	Function	References	QTL	Enriched Biological Process	RNA-seq analysisa		Log2FC	q-value	RT-qPCR analysisb		FC	q-value
					High (RPKM)	Low (RPKM)			High (RQ)	Low (RQ)
HPGD	Biosynthesis of prostaglandins (PTG)	Atli MO et al. 2010	–	Female pregnancy (GO:0007565)	102.14	28.40	1.85	0.032	0.271	0.160	1.69	0.118
		Palliser HK et al. 2014
		Kowalewski MP et al. 2014
MMP8	Collagen metabolism and preeclampsia	Mousa AA et al. 2012	NNIP	Embryo development (GO:0009790)	68.49	8.64	2.99	0.008	0.152	0.034	4.44	0.013
	Remodeling of the cervical and fetal membrane ECM	Wang H et al. 2004
PTGS2	Converts arachidonic acid to PGH2	Waclawik A. et al. 2011	GEST	Maternal placenta development (GO:0001893)	109.91	6.57	4.06	0.008	0.129	0.037	3.50	0.027
		Blitek A. t al. 2006
	Rate-limiting enzymes in PG synthesis	Blitek A. et al. 2006
		Sales KJ et al. 2003
	Essential to reproduction	Murakami M. et al. 2004
		Lim H et al. 1997
		Langenbach R et al. 1999
		Silver RM et al. 1995
PTHLH	Nipple development during pregnancy	Martínez-Giner M et al. 2011	NSB	Lactation	286.09	14.36	4.32	0.008	0.108	0.029	3.69	0.027
	Preimplantation	Guo L et al. 2012
	Fetoplacental development	Thota CS et al. 2005
	Embryonic mammary development	Hiremath M et al. 2013
SCNN1G	Preeclaampsia	Marino G et al. 2013	OVRATE	Response to hypoxia (GO:0001666)	33.29	2.65	3.65	0.008	0.140	0.041	3.42	0.048
			BW	Sodium ion transport (GO:0006814)

^aIn the RNAseq analysis, expression values are shown as RPKM values (Reads per Kilobase of exon model per Million mapped reads) and mean difference between groups as the log₂ transformed fold change (Log₂FC).

^bIn the RT-qPCR analysis, expression values are shown as mean relative quantities (RQ) and mean difference between groups is represented as the fold change (FC).