Table 3. Results summary for the validated candidate miRNAs.
miRNA | Function | References | DEG predicted as target |
RNAseq analysisa |
RT-qPCR analysisb |
||||||
---|---|---|---|---|---|---|---|---|---|---|---|
High (RPKM) | Low (RPKM) | Log2 FC | q-value | High (RQ) | Low (RQ) | FC | q-value | ||||
ssc-miR-92a | Angiosenesis | Bellera N.et al., 2014 | HPGD | 51,874.13 | 21,710.41 | −1.26 | 0.032 | 0.376 | 0.347 | 1.09 | 0.515 |
Embryo implantation | Su L.et al., 2014 | ||||||||||
Placentation | Su L.et al., 2014 | ||||||||||
trophoblast differentiation | Kumar P.et al., 2013 | ||||||||||
ssc-miR-101 | Ginecological tumors | Torres A.et al., 2010 | HTRA3, ATP1B1, PTGS2, JUNB | 430.21 | 187,19 | −1.20 | 0.034 | 0.231 | 0.247 | 0.94 | 0.829 |
Embryo implantation | Chakrabarty A.et al., 2007 | ||||||||||
Endometriosis | Teague E.et al., 2010 | ||||||||||
ssc-miR-133a | Uterine tumors | Torres A.et al., 2010 | ENPEP | 533.76 | 1,777.17 | 1.74 | 0.050 | 0.168 | 0.255 | 0.66 | 0.290 |
Skeletal muscle development | Lee J.et al., 2013 | ||||||||||
ssc-miR-181d | Hypoxia | Shen G.et al., 2013 | MMP8, MME | 55.51 | 124.35 | 1.16 | 0.046 | 0.580 | 0.611 | 0.95 | 0.698 |
Embryo implantation | Su L.et al., 2014 | ||||||||||
Placentation | Su L.et al., 2014 | ||||||||||
Endometrial stromal decidualization | Estella C.et al., 2012 |
aIn the RNAseq analysis, expression values are shown as RPKM values (Reads per Kilobase of exon model per Million mapped reads) and mean difference between groups as the log2 transformed fold change (Log2FC).
bIn the RT-qPCR analysis, expression values are shown as mean relative quantities (RQ) and mean difference between groups is represented as the fold change (FC).