Figure 3.

MHCI receptor induction with aging and sex differences across CNS regions is distinct. Expression of the MHCI receptors, CD247, Klra2, and Lilrb3 are induced with aging in most of the brain regions examined with the exception of the hippocampus. In some regions, for example, cortex and cerebellum, significantly higher expression was evident in females. Y=Young, A=Adult, O=Old/Aged. Two-way analysis of variance (Age × Sex), **p < .01, ***p < .001 Age effect, ^## p < .01, ^### p < .001 Sex effect, ^p < .05, ^^^p < .001 interaction, Benjamini–Hochberg Multiple Testing Correction, n.s. not significant, n = 7–8/group (age/sex/region).