Table 2.

Mean Genetic Contribution of the Common Ancestors in the 10 Index cases (IC) Carrying the SDHC Mutation and the 3 Control Genealogies

Ancestors						Mean Genetic Contribution per Individuals				Genetic Contribution IC/Mean of Controls
Couple	Gender	Place of Marriage	Date of Marriage	Origin	Migration State	IC	C1	C2	C3
D	M	Montréal, Canada	1654	France	Immigrant	0.003 540	0.003 247	0.001 428	0,000 720	1.97
	F			France	Immigrant	0.003 540	0.003 247	0.001 428	0,000 720	1.97
E	M	France	1628	France	Immigrant	0.003 882	0.002 917	0.002 948	0,002 759	1.35
	F			France	Immigrant	0.003 882	0.002 917	0.002 948	0,002 759	1.35
F	M	France	1622	France	Immigrant	0.002 570	0.002 856	0.001 337	0,002 191	1.21
	F			France	France	0.002 570	0.002 856	0.001 337	0,002 191	1.21
A	M	Québec, Canada	1653	France	Immigrant	0.000 964	0.000 610	0.000 537	0,000 464	1.80
	F			France	Immigrant	0.001 990	0.002 002	0.002 148	0,002 710	0.87

Abbreviations: C1, C2, C3, control genealogies; F, female; IC, index case; M, male. The mean genetic contribution of couple D to each index case is of 0.003 540. This means that the probability that the index case had received the mutated SDHC allele from this ancestor is of 0.003 540, which suggest that each index case has a chance on 282 to have received the SDHC mutated gene from this ancestor.