Table 1.
Baseline Characteristics at the Time of Screening in Each Group
| NFG/NGT | NFG/IGT | P Value | |
|---|---|---|---|
| N (males/females) | 25 (9/16) | 19 (5/14) | |
| rs7903146 genotype, TT/CC | 13/12 | 10/9 | .97a |
| Age, y | 48 ± 2 | 50 ± 3 | .65 |
| Body weight, kg | 79 ± 3 | 84 ± 4 | .25 |
| BMI, kg/m2 | 27.3 ± 0.7 | 29.0 ± 0.9 | .12 |
| LBM, kg | 48.6 ± 2.4 | 48.0 ± 1.9 | .84 |
| Screening 75-g 2-h OGTT | |||
| Fasting glucose, mmol/L | 4.8 ± 0.1 | 4.9 ± 0.1 | .69 |
| Peak glucose, mmol/L | 9.0 ± 0.2 | 10.4 ± 0.3 | 4.1 × 10E-5 |
| AAB glucose, mmol/2 h | 266 ± 20 | 435 ± 28 | 1.1 × 10E-5 |
| Fasting insulin, pmol/L | 25 ± 5 | 29 ± 4 | .46 |
| Peak insulin, pmol/L | 289 ± 36 | 328 ± 32 | .43 |
| AAB insulin, nmol/2 h | 19.0 ± 2.6 | 24.2 ± 2.7 | .19 |
| Fasting C-peptide, nmol/L | 0.59 ± 0.03 | 0.77 ± 0.06 | .01 |
| Peak C-peptide, nmol/L | 3.15 ± 0.18 | 3.85 ± 0.27 | .03 |
| AAB C-peptide, nmol per 2 h | 212 ± 14 | 245 ± 19 | .17 |
| Fasting glucagon, ng/L | 81 ± 3 | 88 ± 5 | .24 |
| Nadir glucagon, ng/L | 59 ± 3 | 63 ± 4 | .37 |
| AAB glucagon, ng per 2 h | −2313 ± 249 | −2483 ± 370 | .70 |
Abbreviations: BMI, body mass index; LBM, lean body mass. Values are expressed as means ± SEM. P value reports the results of an unpaired, two-tailed t test.
a
The result of a χ2 test.