Creatinine trend over time in cases 1, 2, and 3. The clinical course of the first (a), second (b), and third (c) cases with immune complex–mediated glomerulonephritis are shown. The time during which the patient was receiving the initial course of direct-acting antiviral (DAA) is shown in shaded gray. AZA, azathioprine; CVVH, continuous venovenous hemofiltration; ICU, intensive care unit; LDV, ledipasvir; MMF, mycophenolate mofetil; Pred, prednisone; RBV, ribavirin; SIM, simeprevir; SOF, sofosbuvir.