Table 3.

Comparison of autoimmune serologic findings before and after DAA treatment

Case	Baseline serologic findings	Post-DAA serologic findings
1	Cryoglobulin: negative Remainder not available	ANA: 1:320 Ds-DNA: negative Anti-histone: ND Anti-RNP: negative Anti-Smith: negative Complement levels C3: 74 (low) C4: 14 Cryoglobulin: negative Rheumatoid factor: Negative Anti–smooth muscle Ab: 1:80 ANCA: Negative
2	ANA: 1:640 in 2007 Cryoglobulin: negative Rheumatoid factor: Positive in 2007 Remainder not available	ANA: >1:5120 Ds-DNA: Positive 1:80 Anti-histone: >7.0 Anti-Ro/La: negative Anti-Smith: negative Complements levels C3: 54 C4: 9 (low) Cryoglobulin: negative Rheumatoid factor: negative
3	ANA: 1:160 Ds-DNA: negative Anti Ro/La: negative Anti-Smith: negative Cryoglobulin level: 5% Complement levels C3: 87 C4: 20 (normal) Rheumatoid factor: negative Remainder not available	ANA: 1:160 Ds-DNA: Negative Anti-histone: 1.5 Units Anti Ro/La: positive Anti-Smith: Negative Cryoglobulin level: 1% Complement levels C3: 42 (low) C4: 7 (low) Rheumatoid factor: negative

Ab, antibody; ANCA, antineutrophil cytoplasmic antibody; ANA, antinuclear antibody; DAA, direct-acting antiviral; Ds-DNA, double-stranded DNA; ND, not done; RNP, ribonucleoprotein.

Normal range for complements levels: C3, 81–157 mg/dl; C4, 12–39 mg/dl. Normal range for antihistone antibody, <1.0 U.