Table 4.
Summary of pathologic characteristics
| Parameter | Case 1 | Case 2 | Case 3 |
|---|---|---|---|
| Light microscopy | |||
| Number of glomeruli | 19 | 9 | 33 |
| Global glomerulosclerosis | 0% | 67% | 9% |
| Segmental glomerulosclerosis | 0% | 0% | 0% |
| Endocapillary hypercellularity | +++ | ++ | +++ |
| Pseudothrombi | + | – | – |
| Mesangial hypercellularity | + | ++ | ++ |
| Segmental GBM duplication | + | + | +++ |
| Crescents | – | – | – |
| Fibrosis and tubular atrophy | <5% | ∼50% | 20% |
| Interstitial inflammation | + | + | ± |
| Tubular injury | ± | + | + |
| Vascular disease | ± | ± | ++ |
| Vasculitis | + hilar arteriole | – | – |
| Immunofluorescence microscopy results | |||
| Glomeruli | |||
| IgG | ++ | ++ | +++ |
| IgA | ++ | +++ | ++++ |
| IgM | + | ++ | ++ |
| C3 | +++ | ++ | +++ |
| C1q | ++ | +++ | ± |
| Fibrin | – | – | +++ |
| Kappa light chain | ++ | +++ | +++ |
| Lambda light chain | ++ | +++ | ++++ |
| Tubules | – | Focal, broad linear IgG and granular C3 | – |
| Interstitium | – | – | – |
| Vessels | – | focal C3 | focal C3 |
| Electron microscopy | |||
| Foot process effacement | segmental | global | segmental |
| Electron-dense deposits | mesangial, paramesangial, subendothelial | mesangial, paramesangial, subendothelial, intramembranous | mesangial, subendothelial, and intramembranous |
| Substructure | – | – | – |
| Tubuloreticular inclusions | + | +++ | – |
| GBM duplication | ± | + | +++ |
| Tubular basement membrane deposits | – | – | – |
GBM, glomerular basement membrane.
In case 3, ± staining for C1q indicates present but minimal staining.