Table 2. Apparent Ki for PDSP hits.
Data are presented as apparent Ki in ng/mL. Ki values are calculated from best-fit IC50 values using the Cheng-Prusoff equation. ND = not determined (fraction was not a hit in the initial screen).
| 5-HT2B | 5-HT2C | 5-HT3 | DOR | KOR | MOR | |
|---|---|---|---|---|---|---|
| Crude | >10,000 | ND | ND | ND | >10,000 | ND |
| A | >10,000 | ND | ND | ND | ND | ND |
| B | >10,000 | ND | ND | ND | ND | ND |
| C | >10,000 | ND | ND | ND | ND | ND |
| D | 8270 | ND | ND | ND | ND | ND |
| E | 6868 | ND | ND | ND | ND | ND |
| F | ND | ND | ND | ND | ND | >10,000 |
| G | ND | ND | ND | ND | ND | >10,000 |
| H | ND | 179 | ND | ND | ND | ND |
| I | ND | 512 | >10,000 | >10,000 | >10,000 | ND |