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. 1976 May;18(2):727–737. doi: 10.1128/jvi.18.2.727-737.1976

Electron microscope studies of temperature-sensitive mutants of herpes simplex virus type 2.

G A Cabral, P A Schaffer
PMCID: PMC515601  PMID: 178905

Abstract

Nine temperature-sensitive mutants of herpes simplex virus type 2 representing eight complementation groups were assigned to two classes as a consequence of the virion forms and virus-specific cellular alterations observed in thin sections of mutant-infected human embryonic lung cells grown at the nonpermissive temperature. Mutants in class A, one DNA- and one DNA +, failed to synthesize detectable virus particles. Mutants in class B, 4DNA- and 3DNA+, produced moderate to large numbers of empty nucleocapsids. Dense-cored nucleocapsids were not observed in thin sections of cells infected with any of the nine mutants at this temperature. Virus-specific cellular alterations consisted primarily of margination of chromating and nulcear membrane thickening and duplication.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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