Scheme 12.
Reaction conditions: (a) NaH, BzCl, DMF, rt; (b) Tosyl chloride, Pyr. 80-100°C; (c) iso-butylamine, MeOH, reflux; (d) (COCl)2, DMSO, CH2Cl2, –78°C, then Et3N, rt; (e) NaBH4, MeOH-THF, rt; (f) NaOMe, MeOH, reflux; (g) TFA-water (4:1).
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