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. Author manuscript; available in PMC: 2016 Dec 14.
Published in final edited form as: Angew Chem Int Ed Engl. 2015 Dec 22;55(5):1614–1650. doi: 10.1002/anie.201502227

Scheme 3.

Scheme 3

Reaction conditions: (a) PTSA, MeOH, reflux; (b) BzCl, pyr., 91%; (c) Pd(OH)2/C, MeOH, (50 psi) H2, 96%; (d) Tf2O, CH2Cl2, pyr., –42°C→ rt, 89%; (e) KOBz, DMSO, 100°C 32%; (f) base (step not shown in original literature).