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Inhibition of caspase-1 and Il-1β production in induced THP-1 cells. Induced THP-1 cells produce inflammasomes, which in turn produce the pro-inflammatory cytokines IL-1β and IL-18.
| Compound | IL-1β production (IC50, μM) |
caspase-1a% inhibitiona |
|---|---|---|
| Berkeleydione (8) | 4.4 | 89 |
| Preaustinoid A (10) | 15.5 | 97 |
| Preaustinoid A1(11) | 34.3 | 77 |
| Berkeleyone A (12) | 2.7 | 68 |
| Berkeleyone B (13) | 3.7 | 100 |
| Berkeleyone C (14) | 37.8 | 0 |
test concentration 100 μg,mL
