Fig 6. Effect of ectopic bcl-2 expression on health, lung damage, and pulmonary CFUs after infection with L. pneumophila.

Weight loss and recovery in CD68(bcl2)tg mice and littermate controls after infection with 1X10⁶ L. pneumophila (A). The histological damage score (HDS) in CD68(bcl2)tg mice and littermate controls 48 hours and 96 hours after infection with L. pneumophila (B). Representative lung histology samples stained with H and E from CD68(bcl2)tg mice 48 hours and 96 hours after infection with L. pneumophila (C). Bacterial CFUs in the lung of CD68(bcl2)tg mice 1, 48, and 96 hours after infection with L. pneumophila as compared to littermate controls (D). These data are representative of at least 3 independent experiments with n = 3–4 per experiment. The mean values are displayed. * denotes P value ≤ 0.05. ** denotes P value ≤ 0.001.