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. 2016 Dec 14;12(12):e1006032. doi: 10.1371/journal.ppat.1006032

Fig 13. Overexpression of bcl-2 rescues other myeloid cell types from S. pyogenes-induced cell death.

Fig 13

Caspase-activation is measured in neutrophils from CD68(bcl2)tg mice and littermate controls after infection with S. pyogenes. A representative staining is shown in (A, left), and the amount of apoptotic cells is quantified (A, right). Caspase-activation is measured in BMDC from CD68(bcl2)tg mice and littermate controls after infection with S. pyogenes. A representative staining is shown in (B, left), and the amount of apoptotic cells is quantified in (B, right). Caspase-activation is measured in resident peritoneal macrophages from CD68(bcl2)tg mice and littermate controls after infection with S. pyogenes. A representative staining is shown in (C, left), and the amount of apoptotic cells is quantified in (C, right). Ex vivo stains of blood from mice infected with S. pyogenes was used to look at apoptosis of neutrophils (D), monocytes (E), and DCs (F). These data are representative of at least 3 independent experiments with n = 3–4 per experiment. The mean values are displayed. * denotes P value < .05.