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. 2016 Dec 14;12(12):e1006045. doi: 10.1371/journal.ppat.1006045

Fig 4. Pre-infection prophylactic effects in intracerebral infection.

Fig 4

(a) Survival of intracerebrally 263K prion-infected Tg7 mice treated with HPMCs. A single subcutaneous injection (4 g/kg body weight) was given at 6, 12, or 19 months before infection. (b) Relationship between pretreatment timing and survival time of animals treated with HPMCs. Medians and quartiles from the data of representative HPMCs in (a) and Fig 1c are plotted. *P < 0.05; **P < 0.01; ***P < 0.005; log-rank test. (c) Relationship between HPMC viscosity and survival time of animals treated 12 or 19 months before infection. Medians and quartiles from the data of (a) are plotted. *P < 0.05; **P < 0.01; ***P < 0.005; log-rank test.