Fig 5. Long-term pharmacokinetics of subcutaneously injected ¹⁴C-TC-5RW.

(a) Radioluminograms of Tg7 mice at 0.5, 3, or 6 months after a single subcutaneous injection of ¹⁴C-TC-5RW (2 g/kg body weight) (n = 1 for each time point). (b) Temporal profile of ¹⁴C-TC-5RW radioactivity levels in each tissue of Tg7 mice given a single subcutaneous ¹⁴C-TC-5RW injection. Radioactive signals in (a) were analyzed in technical triplicates, and the mean and standard deviation are presented. (c) Elimination half-life of ¹⁴C-TC-5RW in each tissue of Tg7 mice given a single subcutaneous ¹⁴C-TC-5RW injection. This half-life was calculated from the data presented in (b). (d) GPC profiles of ¹⁴C-TC-5RW radioactivity extracted from representative tissues of Tg7 mice 8 months after a single subcutaneous ¹⁴C-TC-5RW injection (2 g/kg body weight). The profile of ¹⁴C-TC-5RW used for the study is shown at the bottom.