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. 2016 Dec 14;11(12):e0168188. doi: 10.1371/journal.pone.0168188

Table 2. Sex-related oxylipins.

Compound Δ Precursor Pathway Tendency Ratio P Q Effect
10-HDoHE ω3 DHA - Women>Men 3.8 *** $ $ $ Anti-inflammation/ vasodilation
12-HEPE ω3 EPA 12-LOX Women>Men 5.4 *** $ $ $ Anti-inflammation/ vasodilation
14-HDoHE ω3 DHA 12-LOX Women>Men 18.6 *** $ $ $ Anti-inflammation/ vasodilation
8-HETE ω6 AA P450 Women>Men 3.1 *** $ $ $ Inflammation/ vasodilation
12-HETE ω6 AA 12-LOX Women>Men 24.2 *** $ $ $ Inflammation/ vasodilation

Δ: The first double bond.

-: non-enzymatic.

Ratio represents the median ratio of the value in women to that in men.

***p < 0.001 by the Mann-Whitney U-test.

$ $ $q<0.001 by Benjamini-Hochberg procedure for FDR.