Table 2. Sex-related oxylipins.
Compound | Δ | Precursor | Pathway | Tendency | Ratio | P | Q | Effect |
---|---|---|---|---|---|---|---|---|
10-HDoHE | ω3 | DHA | - | Women>Men | 3.8 | *** | $ $ $ | Anti-inflammation/ vasodilation |
12-HEPE | ω3 | EPA | 12-LOX | Women>Men | 5.4 | *** | $ $ $ | Anti-inflammation/ vasodilation |
14-HDoHE | ω3 | DHA | 12-LOX | Women>Men | 18.6 | *** | $ $ $ | Anti-inflammation/ vasodilation |
8-HETE | ω6 | AA | P450 | Women>Men | 3.1 | *** | $ $ $ | Inflammation/ vasodilation |
12-HETE | ω6 | AA | 12-LOX | Women>Men | 24.2 | *** | $ $ $ | Inflammation/ vasodilation |
Δ: The first double bond.
-: non-enzymatic.
Ratio represents the median ratio of the value in women to that in men.
***p < 0.001 by the Mann-Whitney U-test.
$ $ $q<0.001 by Benjamini-Hochberg procedure for FDR.