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. 2016 Dec 14;11(12):e0168219. doi: 10.1371/journal.pone.0168219

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© 2016 Gao et al

This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Fig 2 — (A) Representative images of Hoechst nuclear staining in each group. The extent of nuclear damage was decreased in the group of GB pretreatment for 30 min followed by DOX-induced cardiotoxicity comparatively to the DOX group. (B) Flow cytometry analysis of the cardiomyocytes apoptosis. Protective effects of GB pretreatment on the apoptosis of cardiomyocytes were demonstrated by Annexin V/PI staining. (C) Quantitative representation of the flow cytometry analysis. Cardiomyocytes apoptosis was inhibited following GB pretreatment for 30 min before DOX-induced cardiotoxicity. (D) and (E) Western-blot analysis of apoptosis related proteins (cleaved caspase 3, Bcl-2 and Bax) in cardiomyocytes after GB pretreatment for 30 min prior to DOX-induced cardiotoxicity. ****p<0.0001 when compared to control group, #p<0.05 ##p<0.01, ###p<0.001 when compared to the DOX group.