Table 3.
Examples of therapeutic native proteins obtained by purification from natural sources.
| Biopharmaceutical | Commercial name | Host organism | Clinical use |
|---|---|---|---|
| Botulinum toxin type A | Botox | Clostridium botulinum | Several kinds of dystonia; cosmetic procedures |
| Botulinum toxin type B | Myoblock | C. botulinum | Several kinds of dystonia; cosmetic procedures |
| Collagenase | Collagenase, santyl | Clostridium histolyticum | Treatment of the chronic dermal ulcers and burned areas |
| l-Asparaginase | Elspar | E. coli | Acute lymphocytic leukemia (ALL) |
| PEG-l-asparaginase | Oncaspar | E. coli | Chemically modified asparaginase (PEGylated) to the ALL treatment |
* Adapted from Leader et al., 2008.